1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water
T=35°C; pH=10; 3.66667 h; Enzymatic reaction;
2: With hydrogenchloride in water
pH=1; optical yield given as percent eeenantioselective reaction;
参考文献
Gong, Xiangyu; Su, Erzheng; Wang, Pixiang; Wei, Dongzhi
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5398 - 5402
1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water
T=35°C; pH=10; 2.33333 h; Enzymatic reaction;
2: With hydrogenchloride in water
pH=1; optical yield given as percent eeenantioselective reaction;
参考文献
Gong, Xiangyu; Su, Erzheng; Wang, Pixiang; Wei, Dongzhi
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5398 - 5402
Herbert, Richard B.; Jackson, Frederick B.; Nicolson, Ian T.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 4 p. 825 - 831
1: concentrated aqueous HCl
2: diethyl ether / und Erhitzen der bei 115grad/0.005 Torr siedenden Anteile des Reaktionsprodukts mit Palladium auf 160-170grad/20 Torr
View Scheme
参考文献
Julian et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 180,182
sodium hydrogencarbonate in water; N,N-dimethyl-formamide
参考文献
Zhmurenko, L. A.; Borisenko, S. A.; Glozman, O. M.; Ostrovskaya, R. U.; Burov, Yu. V.; Zagorevskii, V. A.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 9 p. 612 - 617
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 9 p. 49 - 55
