反应条件
1.1: 74 percent / bromine / CHCl3 / 0 - 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: 71 percent / dimethylformamide / 0 - 20 °C
3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 - 0 °C
3.2: 94 percent / hexane; diethyl ether / -78 - 20 °C
4.1: 89 percent / aq. HCl / methanol / 20 °C
View Scheme
参考文献
Clark, Richard F.; Zhang, Tianyuan; Wang, Xiaojun; Wang, Rongqi; Zhang, Xiaolin; Camp, Heidi S.; Beutel, Bruce A.; Sham, Hing L.; Gu, Yu Gui
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 7 p. 1961 - 1965
