(苯基亚甲基)氨基甲酸叔丁酯合成路线 （共 35 条）
反应条件
1: benzaldehyde N-boc imine With diethylzinc; tri-n-butyl-tin hydride; lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 2 h; Inert atmosphere; 2: carbon dioxide With cesium fluoride in N,N-dimethyl-formamide T=110°C; P=7500.75 Torr; 3 h; Autoclave; 3: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide pH=2; Inert atmosphere;
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
(η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate in tetrahydrofuran; toluene T=35°C; 15 h; Inert atmosphereMolecular sieve;
参考文献
Bartoszewicz, Agnieszka; Jezowska, Martina M.; Laymand, Kevin; Moebus, Juri; Martin-Matute, Belen
European Journal of Inorganic Chemistry, 2012 , # 9 p. 1517 - 1530
反应条件
[Rh(NCMe)2(cod)][BF4] in tetrahydrofuran T=60°C; Phenylation; 20 h;
参考文献
Oi, Shuichi; Moro, Mitsutoshi; Fukuhara, Hiroe; Kawanishi, Takanori; Inoue, Yoshio
Tetrahedron Letters, 1999 , vol. 40, # 52 p. 9259 - 9262
反应条件
1: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C 2: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
1: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 15 min 2: 90 percent / DDQ, 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 3: 100 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 1.) 0 deg C, 30 min, 2.) 20 deg C, 2 h View Scheme
参考文献
Kanazawa; Denis; Greene
Journal of Organic Chemistry, 1994 , vol. 59, # 6 p. 1238 - 1240
反应条件
dirhodium tetraacetate; C15H22OS (chiral); N-benzyl-N,N,N-triethylammonium chloride in 1,4-dioxane T=40°C; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 40, # 8 p. 1433 - 1436
反应条件
N-(4,5-dihydro-3H-4-aza-cyclohepta[2,1-a;3,4-a']dinaphthalen-2-yl)-C,C,C-trifluoro-methanesulfonamide T=0°C; Mannich reaction; 4 h; optical yield given as percent eeenantioselective reaction;
参考文献
Kano, Taichi; Yamaguchi, Yukako; Maruoka, Keiji
Angewandte Chemie - International Edition, 2009 , vol. 48, # 10 p. 1838 - 1840
反应条件
1: acetaldehyde; benzaldehyde N-boc imine With L-proline in acetonitrile T=0 - 20°C; double Mannich reaction; Inert atmosphere; 2: 4-tolualdehyde N-Boc imine in acetonitrile double Mannich reaction; Inert atmosphere;
参考文献
Chandler, Carley; Galzerano, Patrizia; Michrowska, Anna; List, Benjamin
Angewandte Chemie - International Edition, 2009 , vol. 48, # 11 p. 1978 - 1980
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Mader, Mary M.; Edel, Jonathan C.
Journal of Organic Chemistry, 1998 , vol. 63, # 8 p. 2761 - 2764
反应条件
1: 1.) LiN(Si(CH3)3)2 / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 15 min 2: 70 percent / LiOH, H2O2 / tetrahydrofuran; H2O / 15 h / 20 °C 3: 1.) DCC, 2.) DMAP / 1.) toluene, 20 deg C, 5 min, 2.) 20 deg C, 20 h 4: 1.) Zn-Cu, 2.) H2 / 2.) Pd / 1.) CH3COOH, CH3OH, 65 deg C, 30 min, 2.) CH3COOH, 40 deg C, 6 h View Scheme
参考文献
Kanazawa; Denis; Greene
Journal of Organic Chemistry, 1994 , vol. 59, # 6 p. 1238 - 1240
