2-氯-2,2-二氟乙酸甲酯合成路线 （共 95 条）
反应条件
sodium methylate in diethyl ether
参考文献
Moore,R.A.; Levine,R.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1439 - 1444
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=120°C; 8 h; Product distributionMechanism;
参考文献
Su, De-Bao; Duan, Jian-Xing; Yu, An-Juan; Chen, Qing-Yun
Journal of Fluorine Chemistry, 1993 , vol. 65, # 1-2 p. 11 - 14
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=110 - 120°C; 8 h;
参考文献
Su, De-Bao; Duan, Jian-Xing; Chen, Quing-Yun
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7689 - 7690
反应条件
potassium fluoride; copper(l) iodide; cadmium (II) iodide in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=120°C; 8 h;
参考文献
Chen, Qing-Yun; Duan, Jian-Xing
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4241 - 4244
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=120°C; 6 h;
参考文献
ELAN PHARMACEUTICALS, INC.; SHAM, Hing, L.; KONRADI, Andrei, W.; HOM, Roy, K.; PROBST, Gary, D.; BOWERS, Simeon; TRUONG, Anh; NEITZ, R., Jeffrey; SEALY, Jennifer; TOTH, Gergely
Patent: WO2010/91310 A1, 2010 ;
Location in patent: Page/Page column 148 ;
WO 2010/091310 A1
反应条件
sodium methylate in diethyl ether
参考文献
Moore,R.A.; Levine,R.
Journal of Organic Chemistry, 1964 , vol. 29, p. 1439 - 1444
反应条件
potassium fluoride; copper(l) iodide 1.) DMF, 125 deg C, 1 h, 2.) DMF, 125 deg C, 8 h; Yield givenMultistep reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 93, # 1 p. 73 - 79
反应条件
potassium fluoride; copper(l) iodide; iodine in N,N-dimethyl-formamide T=120°C; 3 h;
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 11 p. 807 - 808
反应条件
potassium fluoride; copper(l) iodide; iodine in N,N-dimethyl-formamide T=120°C; 3 h; other bromodifluoroacetate deriv.; var. temp. and times of reaction; Mechanism;
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 11 p. 807 - 808
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=100°C; 8 h;
参考文献
Su, De-Bao; Duan, Jian-Xing; Chen, Quing-Yun
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7689 - 7690
