2,6-dimethylpyridine in dichloromethane T=35°C; 1 h;

pyridine in dichloromethane T=-40 - 20°C;

N-ethyl-N,N-diisopropylamine in dichloromethane

N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Inert atmosphere;

1,3-bis-(diphenylphosphino)propane; palladium diacetate

potassium fluoride; tris-(dibenzylideneacetone)dipalladium(0); t-Bu Brett Phos; potassium bromide in 1,4-dioxane T=130°C; 16 h; Inert atmosphere;

1.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere 1.2: 0 °C / Inert atmosphere 2.1: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / toluene / 24 h / 110 °C / Inert atmosphere 3.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C View Scheme

sodium hydrogencarbonate; Pd(PPh3)4 in N,N-dimethyl-formamide

Pd(1,3-bis(diphenylphosphino)-propane)Cl2 in diethyl ether T=0°C; 2 h; Title compound not separated from byproducts;

lithium bromide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran T=-20 - 80°C; Inert atmosphere;