N,N-二甲基-4-硝基苄胺合成路线 （共 25 条）
反应条件
in water; isobutyl methylketone
T=20 - 35°C;
参考文献
Roth, Gerald J.; Heckel, Armin; Colbatzky, Florian; Handschuh, Sandra; Kley, Joerg; Lehmann-Lintz, Thorsten; Lotz, Ralf; Tontsch-Grunt, Ulrike; Walter, Rainer; Hilberg, Frank
Journal of Medicinal Chemistry, 2009 , vol. 52, # 14 p. 4466 - 4480
反应条件
1: benzene / Heating
2: aq. NaOH
3: aq. HCl / Heating
4: NaOMe / methanol
View Scheme
参考文献
Wawzonek,S.; Yeakey,E.
Journal of the American Chemical Society, 1960 , vol. 82, p. 5718 - 5721
反应条件
titanium tetrachloride in dichloromethane
T=20°C; 48 h;
参考文献
Miura; Ootsuka; Suda; Nishikori; Hosomi
Synlett, 2001 , # 10 p. 1617 - 1619
反应条件
triethylamine in dichloromethane
T=20°C; 3 h;
参考文献
Murugesan, Dinakaran; Mital, Alka; Kaiser, Marcel; Shackleford, David M.; Morizzi, Julia; Katneni, Kasiram; Campbell, Michael; Hudson, Alan; Charman, Susan A.; Yeates, Clive; Gilbert, Ian H.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2975 - 2990
反应条件
1: aq. HCl / Heating
2: NaOMe / methanol
View Scheme
参考文献
Wawzonek,S.; Yeakey,E.
Journal of the American Chemical Society, 1960 , vol. 82, p. 5718 - 5721
反应条件
1: With sulfuric acid
2: Alkaline conditions;
参考文献
Cedilote, Miall; Cleary, Thomas Patrick; Zhang, Pingsheng
Patent: US2007/255057 A1, 2007 ;
Location in patent: Page/Page column 1; 4 ;
反应条件
1: With tert-butyl methyl ether; nitric acid in tetrahydrofuran
T=0°C;
2: With sulfuric acid in dichloromethane
T=0°C; 1 h; Further stages. Title compound not separated from byproducts.;
参考文献
Zhang, Pingsheng; Cedilote, Miall; Cleary, Thomas P.; Pierce, Michael E.
Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8659 - 8664
参考文献
Sharma; Kaur, Sukhvir
Journal of the Indian Chemical Society, 2007 , vol. 84, # 6 p. 612 - 614
参考文献
Goss; Ingold; Wilson
Journal of the Chemical Society, 1926 , p. 2458
反应条件
in chloroform; acetic acid
Kinetics; mixing the dimer cyclopalladated complex in CHCl3 and 2-phenylpyridine in HOAc with glacial acetic acid, thermostating (75°C); not isolated; spectrophotometrical detn.;
参考文献
Ryabov, Alexander D.
Inorganic Chemistry, 1987 , vol. 26, p. 1252 - 1260
