反应条件
1.1: iodine; magnesium / tetrahydrofuran / 0 °C / |Reflux; |Inert atmosphere
1.2: 10 - 20 °C / |Inert atmosphere
2.1: sodium hydroxide / water; methanol / 20 °C / |Inert atmosphere
3.1: N,N-dimethyl-formamide / 20 h / 70 °C / |Inert atmosphere
3.2: 24 h / 70 °C / |Inert atmosphere
4.1: toluene / 2 h / |Inert atmosphere
View Scheme
参考文献
Allmendinger, Thomas; Bixel, Dominique; Clarke, Adrian; Di Geronimo, Laura; Fredy, Jean-Wilfried; Manz, Marco; Gavioli, Elena; Wicky, Regine; Schneider, Martin; Stauffert, Fabien J.; Tibi, Markus; Valentekovic, Darko
Organic Process Research and Development, 2012 , vol. 16, # 11 p. 1754 - 1769