2-(4-溴苄基)异吲哚啉-1,3-二酮合成路线 （共 6 条）
反应条件
ammonium cerium (IV) nitrate in water; acetone T=20 - 25°C; 0.666667 h; Inert atmosphere;
参考文献
Terent'ev, Alexander O.; Krylov, Igor B.; Sharipov, Mikhail Y.; Kazanskaya, Zoya M.; Nikishin, Gennady I.
Tetrahedron, 2012 , vol. 68, # 50 p. 10263 - 10271,9
反应条件
p-toluenesulfonic acid monohydrate; triethylamine in chloroform; toluene
参考文献
Bayer Corporation
Patent: US6165800 A1, 2000 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=25°C; Mitsunobu reaction; 72 h;
参考文献
Hoertner, Simone R.; Ritschel, Tina; Stengl, Bernhard; Kramer, Christian; Schweizer, W. Bernd; Wagner, Bjoern; Kansy, Manfred; Klebe, Gerhard; Diederich, Francois
Angewandte Chemie - International Edition, 2007 , vol. 46, # 43 p. 8266 - 8269
反应条件
1: phthalimide With potassium carbonate in dimethyl sulfoxide T=120°C; 2 h; 2: 4-bromo-benzyl bromide in dimethyl sulfoxide T=50°C; 10 h;
参考文献
RATIOPHARM GMBH
Patent: WO2006/81807 A2, 2006 ;
Location in patent: Page/Page column 16; 18; 23 ;
反应条件
in N,N-dimethyl-formamide T=120°C; 15 h; Inert atmosphere;
参考文献
Luethy, Monique; Schenk, Kurt; Renaud, Philippe
Chemistry - A European Journal, 2010 , vol. 16, # 33 p. 10171 - 10177
反应条件
1: With hydrazine hydrate in ethanol 1.5 h; Inert atmosphereReflux; 2: With hydrogenchloride in ethanol; water T=90°C; 15 h; Inert atmosphere; 3: With sodium hydroxide in ethanol; water Inert atmosphere;
参考文献
Chemistry - A European Journal, , vol. 16, # 33 p. 10171 - 10177
