4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸甲酯合成路线 （共 12 条）
反应条件
AlCl3, aluminium chloride Friedel Crafts Acylation;
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=-10 - 44°C; Inert atmosphereReflux; 2: With hydrogenchloride; water in dichloromethane; water T=15 - 20°C;
参考文献
WO2011/141928 A1, ;
Page/Page column 18-19 ;
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating 2: 79 percent / POCl3, pyridine / 100 °C 3: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h 4: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 36, # 7 p. 701 - 712
反应条件
1: 45 percent / AlCl3 / 2 h / 0 - 20 °C 2: 87 percent / LiAlH4 / diethyl ether / 1 h / Heating 3: 79 percent / POCl3, pyridine / 100 °C 4: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h 5: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 36, # 7 p. 701 - 712
反应条件
1: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h 2: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 36, # 7 p. 701 - 712
反应条件
1: 79 percent / POCl3, pyridine / 100 °C 2: 80 percent / H2 / 10percent Pd/C / ethyl acetate / 1 h 3: 67 percent / AlCl3 / CH2Cl2 / 0.25 h / Heating View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 36, # 7 p. 701 - 712
反应条件
1: Methyltriphenylphosphonium bromide With sodium amide in tetrahydrofuran Inert atmosphere; 2: methyl 4-lt;(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonylgt;benzoate in tetrahydrofuran Wittig reaction; 1 h; Inert atmosphere;
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: Methyltriphenylphosphonium bromide With potassium hexamethylsilazane in toluene T=25 - 50°C; 0.75 h; Inert atmosphere; 2: methyl 4-lt;(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonylgt;benzoate in toluene T=0 - 5°C; 2 h; Inert atmosphere;
参考文献
IND-SWIFT LABORATORIES LIMITED; BHIRUD, Shekhar, Bhaskar; SARIN, Gurdeep, Singh; SHARMA, Bimal, Kumar; GERA, Pardeep
Patent: WO2011/141928 A1, 2011 ;
Location in patent: Page/Page column 19 ;
