4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸合成路线 （共 7 条）
反应条件
sodium hydroxide in methanol 2 h; Heating;
参考文献
Faul; Ratz; Sullivan; Trankle; Winneroski
Journal of Organic Chemistry, 2001 , vol. 66, # 17 p. 5772 - 5782
反应条件
1: With AlCl3, aluminium chloride in dichloromethane T=-10 - 44°C; Inert atmosphereReflux; 2: With hydrogenchloride; water in dichloromethane; water T=15 - 20°C;
参考文献
WO2011/141928 A1, ;
Page/Page column 18-19 ;
反应条件
1: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 2: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: HCl conc. / 3 h / 20 °C 2: 99 percent / AlCl3 / CH2Cl2 / 20 °C 3: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 4: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 99 percent / AlCl3 / CH2Cl2 / 20 °C 2: 81 percent / FeCl3 / 1,2-dichloro-ethane / 16 h / 75 °C 3: 100 percent / aq. NaOH / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 66, # 17 p. 5772 - 5782
反应条件
1: 64 percent / AlCl3 / 1,2-dichloro-ethane / 16 h / Ambient temperature 2: 89 percent / KOH / methanol; H2O / 1 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 17 p. 3368 - 3383
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / -10 - 44 °C / Inert atmosphere; Reflux 1.2: 15 - 20 °C 2.1: potassium hydroxide; water / methanol / 25 °C / Reflux 2.2: 20 - 25 °C View Scheme
