1,6-二溴-1,6-二脱氧-D-甘露醇2,3,4,5-四乙酸酯合成路线 （共 8 条）
反应条件
1: [14C]-D-(-)-Mannitol With acetyl-bromide in 1,4-dioxane
T=20 - 40°C;
2: acetic anhydride With pyridine
T=20°C; Further stages.;
参考文献
Schmidt, Bernd; Nave, Stefan
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 1-2 p. 215 - 230
反应条件
1: AcBr / dioxane
2: pyridine
View Scheme
参考文献
Burke, Steven D.; Sametz, Geoffrey M.
Organic Letters, 1999 , vol. 1, # 1 p. 71 - 74
参考文献
Overend et al.
Journal of the Chemical Society, 1948 , p. 2201
反应条件
pyridine
1) 1,4-dioxane, r.t., 72 h; Yield given. Multistep reaction;
参考文献
El Anzi, Aniss; Benazza, Mohammed; Frechou, Catherine; Demailly, Gilles
Tetrahedron Letters, 1993 , vol. 34, # 23 p. 3741 - 3744
反应条件
pyridine; acetyl-bromide
1.) dioxane, room temperature, 72 h, 2.) overnight; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Crombez-Robert, Caroline; Benazza, Mohammed; Frechou, Catherine; Demailly, Gilles
Carbohydrate Research, 1997 , vol. 303, # 3 p. 359 - 365
反应条件
1: CCl4; PBr3 / 50 °C
2: sodium acetate
View Scheme
参考文献
Overend et al.
Journal of the Chemical Society, 1948 , p. 2201
反应条件
pyridine; hydrogen bromide; acetic anhydride
1) 1,4-dioxane, r.t., 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
El Anzi, Aniss; Benazza, Mohammed; Frechou, Catherine; Demailly, Gilles
Tetrahedron Letters, 1993 , vol. 34, # 23 p. 3741 - 3744
反应条件
pyridine; hydrogen bromide
1) 1,4-dioxane, r.t., 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
El Anzi, Aniss; Benazza, Mohammed; Frechou, Catherine; Demailly, Gilles
Tetrahedron Letters, 1993 , vol. 34, # 23 p. 3741 - 3744
