hydroxylamine hydrochloride; potassium hydroxide in methanol 24 h; Reflux;

1,4-diaza-bicyclo[2.2.2]octane; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in methanol Lossen Rearrangement; 3 h; RefluxGreen chemistry;

(i) NaH, benzene, (ii) /BRN= 1865064/, (iii) Et3N; Multistep reaction;