n-butyllithium; N,N,N',N,-tetramethylethylenediamine in tetrahydrofuran; hexane 1.) -45 deg C, 160 min, 2.) r.t., 19 h;

Zn4O (OCOCF3)6(CF3COOH)n in chlorobenzene 12 h; Inert atmosphereReflux; Product distribution / selectivity;

1: N-((1E)-((3R,8R)-3,8-diethyl-7-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-3,4,6,7,8,9-hexahydrodipyrido(3,4-b:3',4'-e)pyrazin-2(1H)-yl)(phenyl)methylene)-N-((1S)-1-(methoxymethyl)-2-methylpropyl)amine With boron tribromide in dichloromethane T=-78 - 20°C; 5 h; 2: di-tert-butyl dicarbonate With sodium hydroxide in tetrahydrofuran; water

n-butyllithium in diethyl ether; hexane T=-78°C; 1 h;

bismuth trifluoromethanesulphonate 5.5 h; Heating;

copper(II) bis(trifluoromethanesulfonate); diisopropyl-carbodiimide in 1,4-dioxane 5 h; Heating;

Zn4(OCOCF3)6O in chlorobenzene 12 h; Heating / reflux; Product distribution / selectivity;

Zn4(OCOCF3)6O in chlorobenzene 12 h; Heating / reflux; Product distribution / selectivity;

in 1,2-dichloro-ethane 15 h; Heating;

1: 4 Angstroem molecular sieves / CH2Cl2 / 14 h / 20 °C 2: N-bromosuccinimide / CH2Cl2 / 0.5 h / 20 °C View Scheme