in water; dimethyl sulfoxide

(R)-DTBM-Segphos; Cu(I)-tert-butoxide in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=20°C; 5.2 h; Title compound not separated from byproducts;

halohydrin dehalogenase from Mycobacterium sp. GP1 (HheB); Tris-SO4 buffer in dimethyl sulfoxide T=22°C; pH=7.5; 5 h; Title compound not separated from byproducts;

1: (E)-1-chlorooctan-2-one With isopropyl alcohol T=30°C; pH=7.5; 4 h; aq. bufferEnzymatic reaction; 2: sodium cyanide With halohydrin dehalogenase from Mycobacterium sp. GP1 T=30°C; pH=7.5; 20 h; aq. bufferEnzymatic reaction; optical yield given as percent ee;