反应条件
1.1: KOH / ethanol
1.2: 89 percent / ethanol; ethyl acetate / 20 °C
2.1: 30 percent / PPA / 6 h / Heating
3.1: 95 percent / N-bromoacetamide / CH2Cl2 / 2 h / 20 °C
4.1: 65 percent / TFA; aq. H2O2 / CH2Cl2 / 2 h / 20 °C
5.1: NaH / dimethylformamide / 0.33 h
5.2: 94 percent / dimethylformamide / 1 h / 20 °C
6.1: HCl / CH2Cl2; diethyl ether / 1 h
6.2: 85 percent / TMSCl; Ph3P / tetrahydrofuran / 8 h / Heating
7.1: HCl / CH2Cl2; diethyl ether / 0.5 h / 20 °C
7.2: 82 percent / BF3*SMe2 / CH2Cl2 / 5 h / 20 °C
8.1: 85 percent / CuI; ethyl acetate / dimethylformamide; methanol / 8 h / 110 °C
View Scheme
参考文献
Qin, Zhihui; Kastrati, Irida; Chandrasena, R. Esala P.; Liu, Hong; Yao, Ping; Petukhov, Pavel A.; Bolton, Judy L.; Thatcher, Gregory R. J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 11 p. 2682 - 2692
