1-溴-4-(2,2,2-三氟乙基)-苯合成路线 （共 6 条）
反应条件
copper(l) iodide in 1-methyl-pyrrolidin-2-one T=20 - 80°C;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/21489 A1, 2011 ;
Location in patent: Page/Page column 30 ;
反应条件
potassium fluoride; 18-crown-6 ether in N,N-dimethyl-formamide T=70°C; hydrofluorination; 4 h;
参考文献
Lee, Chuan-Chen; Lin, Shaw-Tao
Journal of Chemical Research - Part S, 2000 , # 3 p. 142 - 144
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=100°C; 10 h;
参考文献
Duan, Jian-Xing; Chen, Quing-Yun
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 725 - 730
反应条件
copper in acetonitrile T=60°C; 9 h; Inert atmosphere;
参考文献
Zhu, Lingui; Liu, Shasha; Douglas, Justin T.; Altman, Ryan A.
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12800 - 12805
反应条件
1: 82 percent / pyridine / 0.17 h / 0 - 10 °C 2: 72 percent / CuI / dimethylformamide / 8 h / 70 °C View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 6 p. 725 - 730
反应条件
1.1: tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 18 h / 100 °C 2.1: borane-THF / tetrahydrofuran / 18 h / 60 °C 2.2: 2 h / Reflux View Scheme
参考文献
MacSari, Istvan; Besidski, Yevgeni; Csjernyik, Gabor; Nilsson, Linda I.; Sandberg, Lars; Yngve, Ulrika; Ahlin, Kristofer; Bueters, Tjerk; Eriksson, Anders B.; Lund, Per-Eric; Venyike, Elisabet; Oerther, Sandra; Hygge Blakeman, Karin; Luo, Lei; Arvidsson, Per I.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 15 p. 6866 - 6880
