n-butyllithium; water; (R)-3,3'-dibromo-[1,1'-binaphthalene]-2,2'-diol in tetrahydrofuran; hexane
T=-23°C; aldol reaction; 0.5 h; Title compound not separated from byproducts;
1: cyclohexanone With (S)-N-cyclopropyl-pyrrolidine-2-carboxamide; acetic acid in m-xylene
T=20°C; 0.166667 h;
2: benzaldehyde in m-xylene
T=-20°C; 48 h; optical yield given as percent eeenantioselective reaction;
1: With titanium tetrachloride in dichloromethane
T=0°C; 1 h; Inert atmosphere;
2: With sodium hydrogencarbonate in water
T=0°C; Inert atmosphere; optical yield given as percent ee;
参考文献
Miyakawa, Kenichi; Konakahara, Takeo; Sakai, Norio; Kozawa, Kozo; Gunji, Takahiro; Nagao, Yukinori
Journal of Chemical Research, 2009 , # 1 p. 46 - 51
