N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
tetra-(n-butyl)ammonium iodide in water T=80°C; 8 h; optical yield given as percent ee;
参考文献
Feng, Jie; Liang, Shuai; Chen, Shan-Yong; Zhang, Ji; Fu, Song-Sen; Yu, Xiao-Qi
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 7 p. 1287 - 1292
参考文献
Pharmacor Inc.
Patent: US6362165 B1, 2002 ;
反应条件
chloro-trimethyl-silane; phenol in dichloromethane Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 29, # 3 p. 303 - 306
参考文献
Kumar, I. M. Krishna; Mathew, Beena
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 4 p. 916 - 920
反应条件
1: N-tert-butoxycarbonyl-L-alanine With sodium hydride in tetrahydrofuran T=-10 - 0°C; 0.5 h; 2: benzyl bromide in tetrahydrofuran T=-10 - 20°C; 60 h; 3: With hydrogenchloride; water T=0 - 5°C; pH=3 - 4;
参考文献
PFIZER INC.
Patent: WO2008/125945 A2, 2008 ;
Location in patent: Page/Page column 20-21 ;
WO 2008/125945 A2
反应条件
Yield given. Multistep reaction;
参考文献
Gaudreau, Pierrette; Paradis, Helene; Langelier, Yves; Brazeau, Paul
Journal of Medicinal Chemistry, 1990 , vol. 33, # 2 p. 723 - 730
反应条件
HBTU; DIPEA in N,N-dimethyl-formamide
参考文献
GKL-Biotec AG
Patent: US2012/10149 A1, 2012 ;
反应条件
1: 93 percent / 1H-benzotriazol-1-yl-N-oxytrispyrrolidinophosphonium PF6(1-); N-ethyldiisopropylamine / tetrahydrofuran; dimethylformamide; diethyl ether / 0.25 h / 0 °C 2: 88 percent / silver benzoate / dioxane; H2O / 70 °C View Scheme
参考文献
Rae, Alastair; Aliev, Abil E.; Edgar Anderson; Castro, Jose L.; Ker, James; Parsons, Simon; Stchedroff, Marc; Tabor, Alethea B.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 14 p. 1933 - 1941
反应条件
1: N-tert-butoxycarbonyl-L-alanine With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran T=-15°C; Arndt-Eistert Homologation; 1 h; 2: diazomethane in tetrahydrofuran Arndt-Eistert Homologation; 3: With silver benzoate; silica gel in ethyl acetate T=50°C; Arndt-Eistert Homologation; 0.5 h;
参考文献
Podwysocka; Kosson; Lipkowski; Olma, Aleksandra
Journal of Peptide Science, 2012 , vol. 18, # 9 p. 556 - 559
反应条件
1: N-tert-butoxycarbonyl-L-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; Claisen Condensation; 2 h; Inert atmosphere; 2: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran T=20°C; Claisen Condensation; 24 h; Inert atmosphere; Overall yield = 91 percent; Overall yield = 2.23 g;
参考文献
Groselj, Uros; Zorz, Mojca; Golobic, Amalija; Stanovnik, Branko; Svete, Jurij
Tetrahedron, 2013 , vol. 69, # 52 p. 11092 - 11108
