N-叔丁氧羰基-L-丙氨酸合成路线 （共 171 条）
反应条件
1: tetrahydrofuran / 0.5 h / Ambient temperature 2: MgCl2 / tetrahydrofuran / 50 °C View Scheme
参考文献
Mansour, Tarek S.; Evans, Colleen A.
Synthetic Communications, 1990 , vol. 20, # 5 p. 773 - 781
反应条件
1: N-tert-butoxycarbonyl-L-alanine With 1,1'-carbonyldiimidazole in tetrahydrofuran Acylation; 2: mono-methyl malonate potassium salt With magnesium chloride in tetrahydrofuran Acylation; decarboxylation;
参考文献
Rendina; Taylor; Gibson; Lorimer; Rayner; Lockett; Kranis; Wexler; Marcovici-Mizrahi; Nudelman; Marsilii; Chi; Wawrzak; Calabrese; Huang; Jia; Schneider; Lindqvist; Yang
Pesticide Science, 1999 , vol. 55, # 3 p. 236 - 247
反应条件
1,1'-carbonyldiimidazole 1.) THF, r.t., 1 h, 2.) THF, r.t., 14 h; Yield given. Multistep reaction;
参考文献
Hashiguchi, Shohei; Kawada, Akira; Natsugari, Hideaki
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 10 p. 2435 - 2444
反应条件
1: ethyl chloroformate; triethylamine; ammonia(g) / CH2Cl2 / -10 °C 2: cyanuric chloride / dimethylformamide / 0.5 h / 20 °C View Scheme
参考文献
Martinez, Veronica; Davyt, Danilo
Tetrahedron Asymmetry, 2013 , vol. 24, # 24 p. 1572 - 1575
反应条件
chloro-trimethyl-silane; phenol in dichloromethane Ambient temperature;
参考文献
Kaiser, Emil; Tam, James P.; Kubiak, Teresa M.; Merrifield, R. B.
Tetrahedron Letters, 1988 , vol. 29, # 3 p. 303 - 306
反应条件
silica gel in hexane T=20°C; Decarboxylation; oxidation; 36 h; UV-irradiation;
参考文献
Itoh, Akichika; Kodama, Tomohiro; Inagaki, Shinji; Masaki, Yukio
Chemistry Letters, 2000 , # 5 p. 542 - 543
反应条件
(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Valverde, Ibai E.; Bauman, Andreas; Kluba, Christiane A.; Vomstein, Sandra; Walter, Martin A.; Mindt, Thomas L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8957 - 8960
Angew. Chem., 2013 , vol. 125, # 34 p. 9126 - 9129,4
反应条件
dicyclohexyl-carbodiimide in chloroform
参考文献
Zhou, Zheng Hong; Tang, Yi Long; Li, Kang Ying; Liu, Bing; Tang, Chu Chi
Heteroatom Chemistry, 2003 , vol. 14, # 7 p. 603 - 606
反应条件
1: CH2Cl2 / 0.5 h / 0 °C 2: Et3N / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
White, Jonathan M.; Tunoori, Ashok Rao; Turunen, Brandon J.; Georg, Gunda I.
Journal of Organic Chemistry, 2004 , vol. 69, # 7 p. 2573 - 2576
反应条件
1: 4-methyl-morpholine / ethylene glycol dimethyl ether / |Inert atmosphere 2: sodium tetrahydroborate / water / |Inert atmosphere 3: triethylamine / |Inert atmosphere 4: dimethyl sulfoxide / |Inert atmosphere View Scheme
参考文献
Xin, Dongyue; Perez, Lisa M.; Ioerger, Thomas R.; Burgess, Kevin
Angewandte Chemie - International Edition, 2014 , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., 2014 , vol. 126, # 14 p. 3668 - 3672,5
