1-BOC-2-哌啶甲醛合成路线 （共 16 条）
反应条件
pyridine-SO3 complex; dimethyl sulfoxide; triethylamine in dichloromethane T=0°C; Parikh-Doering oxidation; 1 h;
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.666667 h; 2: With water in tetrahydrofuran; ethyl acetate
参考文献
RICHTER GEDEON VEGYESZETI GYAR RT.
Patent: WO2007/39782 A1, 2007 ;
Location in patent: Page/Page column 24 ;
WO 2007/039782 A1
反应条件
1: aq. NaOH / dioxane / 20 °C 2: PyBOP; Et3N / CH2Cl2 / 20 °C 3: LiAlH4 / tetrahydrofuran / -15 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 15 p. 4013 - 4017
反应条件
sec-BuLi; N,N,N',N,-tetramethylethylenediamine in N,N-dimethyl-formamide
参考文献
Bowen, J. Phillip; Furness, M. Scott; Whitmire, David
Patent: US6369078 B1, 2002 ;
反应条件
1: 99 percent / acetonitrile / 24 h / 20 °C 2: 95 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.83 h / -78 - 0 °C View Scheme
参考文献
Organic Letters, , vol. 1, # 4 p. 667 - 670
反应条件
1: 99 percent / acetonitrile / 24 h / 20 °C 2: 95 percent / oxalyl chloride; DMSO; Et3N / CH2Cl2 / 0.83 h / -78 - 0 °C View Scheme
参考文献
Organic Letters, , vol. 1, # 4 p. 667 - 670
反应条件
diisobutylaluminium hydride in hexane; toluene T=-78°C;
参考文献
Journal of Organic Chemistry, , vol. 56, # 8 p. 2775 - 2781
反应条件
1: 100 percent / BH3 / tetrahydrofuran / 20 °C 2: 68 percent / NMO; TPAP / CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 19 p. 4861 - 4866
反应条件
1: 93 percent / tetrahydrofuran / 1) 0 deg C, 10 min, 2) to RT, 30 min 2: 1) TMEDA, s-BuLi / 1) diethyl ether, -60 deg C to -20 deg C, 10 min, 2) diethyl ether, -78 deg C, 10 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1109 - 1117
反应条件
1: Et3N 2: DIBAL / toluene; hexane / -78 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 8 p. 2775 - 2781
