1-叔丁氧羰基-4-哌啶乙酸合成路线 （共 30 条）
反应条件
1: sodium hydride / tetrahydrofuran / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethanol 3: water; potassium hydroxide / ethanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1880 - 1886
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol 2: water; potassium hydroxide / ethanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 6 p. 1880 - 1886
反应条件
1: sodium hydrogencarbonate / tetrahydrofuran / 6 h / 25 °C 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 78 °C 3: palladium 10 on activated carbon; hydrogen / ethanol / 7 h / 25 °C 4: sodium hydroxide / methanol / 0.5 h / 25 °C View Scheme
参考文献
Chinese Chemical Letters, , vol. 23, # 6 p. 707 - 710
反应条件
1: triethylamine / tetrahydrofuran / 0.5 h / -15 °C / |Inert atmosphere; |Darkness 2: triethylamine / tetrahydrofuran / 2 h / -15 - 20 °C / |Inert atmosphere; |Darkness 3: silver(l) oxide / water; tetrahydrofuran / 45 °C / |Darkness View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 15 p. 4646 - 4661
反应条件
1: 99 percent / BH3 / tetrahydrofuran / 1 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 20 min, 2.) CH2Cl2, from -78 deg C to RT, 1.5 h 3: CH2Cl2 / Ambient temperature View Scheme
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 2-[1-(tert-butoxycarbonyl)-4-piperidyl]acetic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=20°C; 5 h; 2: malonic acid ethyl ester monopotassium salt With magnesium chloride in tetrahydrofuran T=20°C; 23 h; Heating / reflux; 3: With hydrogenchloride in tetrahydrofuran; water T=0°C; pH=7;
参考文献
PROSIDION LIMITED
Patent: WO2007/3962 A2, 2007 ;
Location in patent: Page/Page column 22 ;
WO 2007/003962 A2
反应条件
borane in tetrahydrofuran 1 h;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 16 p. 2537 - 2551
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
1: 99 percent / BH3 / tetrahydrofuran / 1 h 2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 20 min, 2.) CH2Cl2, from -78 deg C to RT, 1.5 h 3: CH2Cl2 / Ambient temperature 4: 90 percent / H2 / 10percent Pd/C / ethyl acetate 5: 97 percent / NaOH / methanol 6: 98 percent / BH3 / tetrahydrofuran / 1 h 7: 85 percent / Ph3P, CBr4 / tetrahydrofuran; acetonitrile / 24 h View Scheme
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
反应条件
1: 91 percent / BH3*THF 2: 80 percent / pyridine*SO3, DMSO, Et3N View Scheme
参考文献
Egbertson, Melissa S.; Chang, Charles T.-C.; Duggan, Mark E.; Gould, Robert J.; Halczenko, Wasyl; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 16 p. 2537 - 2551
