4-溴-1-甲基-1H-吡唑合成路线 （共 22 条）
反应条件
bromine in dichloromethane T=25 - 29°C; 1.75 h;
参考文献
Mullens, Peter R.
Tetrahedron Letters, 2009 , vol. 50, # 49 p. 6783 - 6786
反应条件
1: 4-bromo(1H)-pyrazole With sodium hydride in tetrahydrofuran T=20°C; 2 h; 2: methyl iodide in tetrahydrofuran T=20°C; 2 h;
参考文献
EP1000062 B1, ;
Page 56 ;
反应条件
in tetrahydrofuran; diethyl ether
参考文献
US6511974 B1, ;
US 6511974 B1
反应条件
potassium hydroxide in ethanol T=78°C; 1.5 h;
参考文献
Ivachtchenko, Alexandre V.; Kravchenko, Dmitry V.; Zheludeva, Valentina I.; Pershin, Dmitry G.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 6 p. 931 - 939
反应条件
anschl. mit CO2 bei -70grad;
参考文献
Huettel; Schoen
Justus Liebigs Annalen der Chemie, 1959 , vol. 625, p. 55,60
反应条件
anschl. mit CO2 bei -70grad;
参考文献
Huettel; Schoen
Justus Liebigs Annalen der Chemie, 1959 , vol. 625, p. 55,60
反应条件
1: 4-bromo-1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.5 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78 - 0°C; 4 h;
参考文献
US2012/214791 A1, ;
Page/Page column 21 ;
US 20120214791 A1
反应条件
sulfuric acid; nitric acid T=100°C; 1 h; different H2SO4 concentration; Product distribution;
参考文献
Perevalov, V. P.; Manaev, Yu. A.; Baryshnenkova, L. I.; Kanep, E. E.; Andreeva, M. A.; Stepanov, B. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1987 , vol. 23, # 10 p. 1081 - 1083
Khimiya Geterotsiklicheskikh Soedinenii, 1987 , # 10 p. 1350 - 1352
反应条件
1: 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane With bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) in pentane T=20°C; 0.166667 - 0.25 h; 2: With 4,4'-di-tert-butyl-2,2'-dipyridyl in pentane 0.333333 h; 3: 4-bromo-1-methyl-1H-pyrazole T=20°C; 5 h; Product distribution / selectivity;
参考文献
Board of Trustees of Michigan State University
Patent: US2008/91027 A1, 2008 ;
Location in patent: Page/Page column 6-7 ;
反应条件
anschliessend mit CO2;<neben anderen Verbindungen>;
参考文献
Huettel; Schoen
Justus Liebigs Annalen der Chemie, 1959 , vol. 625, p. 55,60
