2-硝基-4-溴苯甲酸甲酯合成路线 （共 8 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
SCHERING CORPORATION
Patent: WO2006/19768 A1, 2006 ;
Location in patent: Page column 87 ;
WO 2006/019768 A1
反应条件
sulfuric acid in water 16 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/37796 A1, 2005 ;
Location in patent: Page/Page column 50-51 ;
反应条件
potassium carbonate in acetone T=20 - 50°C; 1 h;
参考文献
WO2006/62093 A1, ;
Page/Page column 55-56 ;
反应条件
potassium carbonate; dimethyl sulfate in water; ethyl acetate; acetone
参考文献
EP1820795 A1, ;
EP 1820795 A1
反应条件
hydrogen; palladium on activated carbon in methanol P=2585.81 Torr; 1 h;
参考文献
NEUROTUNE AG; AHMED, Shaheen; HETTWER, Stefan; VRIJBLOED, Jan Willem; FARINA, Carlo; ALLGEIER, Hans
Patent: WO2012/59442 A2, 2012 ;
Location in patent: Page/Page column 111 ;
WO 2012/059442 A2
反应条件
anhydrous sodium hydrogen carbonate; acetic acid in methanol; hexane; ethyl acetate
参考文献
TOYAMA CHEMICAL CO., LTD.
Patent: EP1820795 A1, 2007 ;
EP 1820795 A1
反应条件
1: in tetrahydrofuran T=-60 - 20°C; Inert atmosphere; 2: With ammonium chloride in tetrahydrofuran; water
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 187 ;
反应条件
sodium hydroxide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate
1.) toluene, reflux, 6 h, 2.) MeOH; Yield given. Multistep reaction;
参考文献
Quan; Wityak; Dominguez; Duncia; Kettner; Ellis; Liauw; Park; Santella; Knabb; Thoolen; Weber; Wexler
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1595 - 1600
