N-BOC-6-羟基-3,4-二氢异喹啉合成路线 （共 22 条）
反应条件
sodium hydroxide in 1,4-dioxane T=20°C; 12 h;
参考文献
Ueno, Hiroshi; Yokota, Katsuyuki; Hoshi, Jun-Ichi; Yasue, Katsutaka; Hayashi, Mikio; Hase, Yasunori; Uchida, Itsuo; Aisaka, Kazuo; Katoh, Susumu; Cho, Hidetsura
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3586 - 3604
反应条件
triethylamine in methanol T=20°C; 3 h;
参考文献
Daiichi Pharmaceutical Co., Ltd.
Patent: US6525042 B1, 2003 ;
反应条件
triethylamine; citric acid in dichloromethane
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5700809 A1, 1997 ;
US 5700809 A
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran; methanol; dichloromethane
参考文献
Eli Lilly and Company
Patent: US5952360 A1, 1999 ;
反应条件
triethylamine in tetrahydrofuran; water T=20°C;
参考文献
Horiuchi, Takao; Nagata, Motoko; Kitagawa, Mayumi; Akahane, Kouichi; Uoto, Kouichi
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 23 p. 7850 - 7860
反应条件
triethylamine in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
US2010/113512 A1, ;
US 20100113512 A1
参考文献
US6562828 B1, ;
US 6562828 B1
反应条件
1: C10H13NO With hydrogen bromide in water T=100°C; Pictet-Spengler cyclisation; 3 h; Reflux; 2: With sodium hydroxide in water 3: di-tert-butyl dicarbonate With sodium hydrogencarbonate in 2-methyl tetrahydrofuran; water T=20°C; Schotten-Baumann reaction; pH=8;
参考文献
Gordon, David W.; Bains, Carol A.
Synthetic Communications, 2010 , vol. 40, # 9 p. 1399 - 1404
反应条件
1: 2-(3-methoxy-phenyl)-ethylamine 2: triethylamine / dichloromethane; ethyl acetate; tetrahydrofuran View Scheme
反应条件
1: ammonium acetate; acetic acid / 12 h / 100 °C 2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 80 °C 3: hydrogenchloride / water / 1 h / 60 °C 4: hydrogenchloride / isopropyl alcohol; water / 18 h / 20 °C 5: hydrogen bromide; water / 5 h / |Reflux 6: triethylamine / tetrahydrofuran; water View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3414 - 3418
