1-[3,5-二(三氟甲基)苯基]膦酰基-3,5-二(三氟甲基)苯合成路线 （共 4 条）
反应条件
monobutyl butyl phosphonate; potassium hydride in diethyl ether 4 h;
参考文献
Casalnuovo, Albert L.; RajanBabu, T. V.; Ayers, Timothy A.; Warren, Timothy H.
Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 9869 - 9882
反应条件
1: 3,5-bis(trifluoromethyl)phenyl bromide With isopropylmagnesium chloride in tetrahydrofuran cooling; 2: phosphonic acid diethyl ester in tetrahydrofuran T=-78 - 20°C;
参考文献
Busacca, Carl A.; Lorenz, Jon C.; Grinberg, Nelu; Haddad, Nizar; Hrapchak, Matt; Latli, Bachir; Lee, Heewon; Sabila, Paul; Saha, Anjan; Sarvestani, Max; Shen, Sherry; Varsolona, Richard; Wei, Xudong; Senanayake, Chris H.
Organic Letters, 2005 , vol. 7, # 19 p. 4277 - 4280
反应条件
phosphorus trichoride in dichloromethane 1.5 h; Yield given;
参考文献
Casalnuovo, Albert L.; RajanBabu, T. V.; Ayers, Timothy A.; Warren, Timothy H.
Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 9869 - 9882
反应条件
diisobutylaluminium hydride in cyclohexane T=20 - 32.4°C;
参考文献
Busacca, Carl A.; Lorenz, Jon C.; Grinberg, Nelu; Haddad, Nizar; Hrapchak, Matt; Latli, Bachir; Lee, Heewon; Sabila, Paul; Saha, Anjan; Sarvestani, Max; Shen, Sherry; Varsolona, Richard; Wei, Xudong; Senanayake, Chris H.
Organic Letters, 2005 , vol. 7, # 19 p. 4277 - 4280
