2-(4-甲氧基苯基)-喹啉合成路线 （共 38 条）
反应条件
diethyl-1,4-dihydro-2,6-dimethyl-3,5-pyridine dicarboxylate; palladium 10 on activated carbon; acetic acid T=120°C; 15 h; Inert atmosphere; chemoselective reaction;
参考文献
Xing, Rui-Guang; Li, Ya-Nan; Liu, Qiang; Han, Yi-Feng; Wei, Xia; Li, Jing; Zhou, Bo
Synthesis, 2011 , # 13 p. 2066 - 2072
反应条件
1: 88 percent / Et2N / Pd(PPh3)4 / dimethylformamide / Ambient temperature 2: 70 percent / 1,1'-bis(diphenylphosphino)ferrocene, Bu4NF, Et3N / PdCl2 / tetrahydrofuran / Ambient temperature 3: 67 percent / HCOONH4 / 10 percent Pd/C / methanol / 1 h / 70 °C View Scheme
参考文献
Mahanty, Jyan S.; De, Mahuya; Das, Palas; Kundu, Nitya G.
Tetrahedron, 1997 , vol. 53, # 39 p. 13397 - 13418
反应条件
1: 62 percent / Et3N; CuI / (Ph3P)2PdCl2 / 24 h / 20 °C 2: 63.5 percent / sodium ethoxide / ethanol / 5 h / Heating View Scheme
参考文献
Kundu, Nitya G.; Mahanty, Jyan S.; Das, Palas; Das, Biswajit
Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1625 - 1628
反应条件
1: α-naphthol; 2-hydroxyquinoline With potassium carbonate; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane T=100°C; 3 h; Inert atmosphere; 2: (4-methoxyphenyl)-boronic acid With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; 4 h; Inert atmosphere; 3: 3,4,5-trimethoxyphenylboronic acid With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in 1,4-dioxane; water T=100°C; Suzuki-Miyaura coupling; 20 h; Inert atmosphere;
参考文献
Li, Shui-Ming; Huang, Jie; Chen, Guo-Jun; Han, Fu-She
Chemical Communications, 2011 , vol. 47, # 48 p. 12840 - 12842
反应条件
1: 70 percent / 1,1'-bis(diphenylphosphino)ferrocene, Bu4NF, Et3N / PdCl2 / tetrahydrofuran / Ambient temperature 2: 67 percent / HCOONH4 / 10 percent Pd/C / methanol / 1 h / 70 °C View Scheme
参考文献
Cacchi, Sandro; Fabrizi, Giancarlo; Marinelli, Fabio
Synlett, 1999 , # 4 p. 401 - 404
反应条件
in N-methyl-acetamide; N,N-dimethyl-formamide; mineral oil
参考文献
Sterling Drug Inc.
Patent: US4049715 A1, 1977 ;
反应条件
potassium hydroxide; tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide in benzene 8 h; Heating;
参考文献
Ishikura, Minoru; Oda, Izumi; Terashima, Masanao
Heterocycles, 1985 , vol. 23, # 9 p. 2375 - 2386
反应条件
iodine; sodium hydrogencarbonate in acetonitrile T=0°C;
参考文献
Okuma, Kentaro; Yasuda, Takumi; Shioji, Kosei; Yokomori, Yoshinobu
Bulletin of the Chemical Society of Japan, 2007 , vol. 80, # 9 p. 1824 - 1827
反应条件
1.1: NaH / tetrahydrofuran / 0.33 h / 20 °C 1.2: 32 percent / tetrahydrofuran / 2 h / 20 °C 2.1: 49 percent / SnCl2*2H2O; conc. HCl / acetic acid / 4 h / 90 °C View Scheme
参考文献
Han, Rongbi; Chen, Shen; Lee, Sun Jung; Qi, Fang; Wu, Xue; Kim, Byeong Hyo
Heterocycles, 2006 , vol. 68, # 8 p. 1675 - 1684
反应条件
1.1: NaH / tetrahydrofuran / 0.33 h / 20 °C 1.2: 32 percent / tetrahydrofuran / 2 h / 20 °C 2.1: 49 percent / SnCl2*2H2O; conc. HCl / acetic acid / 4 h / 90 °C View Scheme
参考文献
Fan, Xuesen; Zhang, Yongmin
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 3 p. 655 - 657
