1,1-二甲基丙-2-炔基乙酸酯合成路线 （共 37 条）
参考文献
Helvetica Chimica Acta, , vol. 42, p. 1945,1954
反应条件
copper(l) iodide; potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=75°C; 6 h;
参考文献
Bell; Davies; Geen; Mann
Synthesis, 1995 , # 6 p. 707 - 712
反应条件
sulfuric acid; mercuric sulphate
参考文献
Bergmann; Herman
Journal of Applied Chemistry, 1953 , vol. 3, p. 42,48
反应条件
1.1: 90 percent / CuI; i-Pr2NEt / tetrahydrofuran / 21 h / 50 °C 2.1: 91 percent / H2 / Lindlar's catalyst / methanol / 10 h / 20 °C / 760 Torr 3.1: 86 percent / MnO2 / toluene / 1 h / 20 °C 4.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 5.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 5.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
参考文献
Nasarow
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1940 , p. 219
Chem.Abstr., 1942 , p. 746
反应条件
palladium-barium carbonate; Petroleum ether
Hydrogenation;
参考文献
Hennion et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 1142
反应条件
aniline; copper(l) chloride in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5693647 A1, 1997 ;
反应条件
triethylamine; copper(l) chloride in tetrahydrofuran
3 h; Heating; Yield given;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=45°C; 0.5 h;
参考文献
Ruitenberg, K.; Kleijn, H.; Westmijze, H.; Meijer, J.; Vermeer, P.
Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 11 p. 405 - 409
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=45°C; 0.5 h;
参考文献
Ruitenberg, K.; Kleijn, H.; Westmijze, H.; Meijer, J.; Vermeer, P.
Recueil: Journal of the Royal Netherlands Chemical Society, 1982 , vol. 101, # 11 p. 405 - 409
