hydrogenchloride in water T=130 - 140°C; Microwave irradiationSealed tube;

<b>Multi-step reaction with 4 steps<br /> </b>1: 85 percent / sulfuric acid / Ambient temperature<br />2: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h<br />3: sodium hydride / dimethylformamide / 48 h / Ambient temperature<br />4: sodium methoxide / dimethylformamide / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 110 - 150 &deg;C<br />2: H₂, conc. HCl / Pd/C / methanol<br />3: DMAP / pyridine / 1.) 0 deg C, 3 h, 2.) room temperature, 48 h<br />4: 64 percent / cesium carbonate / dimethylformamide / 17 h / 100 - 110 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) chlorotrimethylsilane / 1) pyridine, room temperature, 1 h; 2) pyridine, room temperature, 2 h<br />2: sodium hydride / dimethylformamide / 48 h / Ambient temperature<br />3: sodium methoxide / dimethylformamide / Ambient temperature<br /> <br /> &nbsp;