2-甲基-4-(1-哌嗪基)-10H-噻吩并[2,3-b][1,5]苯并二氮杂卓合成路线 （共 8 条）
反应条件
trifluoroacetic acid T=20°C; 3 h;
参考文献
Gao, Mingzhang; Shi, Zenas; Wang, Min; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1953 - 1956
反应条件
potassium hydroxide in ethanol 28 h; Reflux;
参考文献
Gao, Mingzhang; Shi, Zenas; Wang, Min; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 7 p. 1953 - 1956
反应条件
in butan-1-ol 8 h; Heating / reflux; Product distribution / selectivity;
参考文献
LEK PHARMACEUTICALS D.D.
Patent: WO2005/90359 A2, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
in 1-methyl-pyrrolidin-2-one; toluene
参考文献
WO2007/77134 A1, ;
Page/Page column 7 ;
反应条件
1: SnCl2 / ethanol 2: toluene; dimethylsulfoxide / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 25 - 30
反应条件
1: LiOH / dimethylsulfoxide 2: SnCl2 / ethanol 3: toluene; dimethylsulfoxide / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 25 - 30
反应条件
potassium tert-butylate in tetrahydrofuran T=0°C; 2 h; Product distribution / selectivity;
参考文献
LEK PHARMACEUTICALS D.D.
Patent: WO2005/90359 A2, 2005 ;
Location in patent: Page/Page column 21 ;
反应条件
potassium carbonate in methanol T=25°C; 2 h; Product distribution / selectivity;
参考文献
LEK PHARMACEUTICALS D.D.
Patent: WO2005/90359 A2, 2005 ;
Location in patent: Page/Page column 21 ;
