(R)-2,2-二甲基-3-(n-boc)-4-乙炔噁唑啉合成路线 (共 14 条)
反应条件
n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.25 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Branquet, Eric; Meffre, Patrick; Durand, Philippe; Le Goffic, Francois
Synthetic Communications, 1998 , vol. 28, # 4 p. 613 - 622
反应条件
1: (L)-3-tert.butoxycarbonyl-2,2-dimethyl-oxazolidine-4-carboxylic acid-N-methoxy-N-methyl-amide With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester in methanol
T=0°C; 0.5 h; Inert atmosphere;
3: With potassium carbonate in methanol
T=20°C; 15 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
反应条件
ethylmagnesium bromide; triphenylphosphine
THF; Multistep reaction;
参考文献
Cameron, Stuart; Khambay, Bhupinder P.S.
Tetrahedron Letters, 1998 , vol. 39, # 14 p. 1987 - 1990
反应条件
quinoline; Lindlar's catalyst; hydrogen in ethanol
T=20°C; Inert atmosphere;
参考文献
Belanger, Dominique; Tong, Xia; Soumare, Sadia; Dory, Yves L.; Zhao, Yue
Chemistry - A European Journal, 2009 , vol. 15, # 17 p. 4428 - 4436