(R)-(1-羟基甲基-3-丁炔基)-氨基甲酸叔丁酯合成路线 （共 10 条）
反应条件
Amberlist IR-120 in methanol; water 20 h; Ambient temperature;
参考文献
Reginato, Gianna; Mordini, Alessandro; Caracciolo, Massimo
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6187 - 6192
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-Acetylaminobenzenesulfonyl Azide; potassium carbonate in acetonitrile 2 h; 2: N-tert.-butyloxycarbonyl-L-serinal in methanol; acetonitrile T=20°C; 3: With potassium carbonate in methanol; acetonitrile 24 h;
参考文献
CORTEX PHARMACEUTICALS, INC.
Patent: WO2009/38752 A2, 2009 ;
Location in patent: Page/Page column 48-50 ;
反应条件
sodium carbonate in 1,4-dioxane; water T=0°C; Title compound not separated from byproducts;
参考文献
Meffre, Patrick; Gauzy, Laurence; Perdigues, Chantal; Desanges-Levecque, Florence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron Letters, 1995 , vol. 36, # 6 p. 877 - 880
反应条件
1: 1.) PPh3, 2.) Et3N / 1) CH2Cl2, -20 deg C, 30 min; 2) CH2Cl2, -60 deg C, 30 min, rt, overnight 2: 79 percent / BuLi / tetrahydrofuran / 1) -78 deg C, 30 min; 2) -15 deg C, 15 min 3: 65 percent / Amberlist IR-120 (PLUS) / methanol; H2O / 20 h / Ambient temperature View Scheme
参考文献
Reginato, Gianna; Mordini, Alessandro; Caracciolo, Massimo
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6187 - 6192
反应条件
1: 79 percent / BuLi / tetrahydrofuran / 1) -78 deg C, 30 min; 2) -15 deg C, 15 min 2: 65 percent / Amberlist IR-120 (PLUS) / methanol; H2O / 20 h / Ambient temperature View Scheme
参考文献
Reginato, Gianna; Mordini, Alessandro; Caracciolo, Massimo
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6187 - 6192
反应条件
sodium hydrogencarbonate; sodium carbonate in 1,4-dioxane 1.) 0 deg C, overnight, 2.) 25 deg C, 8 h; Yield given;
参考文献
Meffre, Patrick; Gauzy, Laurence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron, 1996 , vol. 52, # 34 p. 11215 - 11238
反应条件
jones reagent; hydrogen; palladium on activated charcoal 1.) acetone, 0 deg C, 2 h, 2.) CH3OH, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Meffre, Patrick; Gauzy, Laurence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron, 1996 , vol. 52, # 34 p. 11215 - 11238
反应条件
1: Jones reagent 2: H2 View Scheme
参考文献
Meffre, Patrick; Gauzy, Laurence; Perdigues, Chantal; Desanges-Levecque, Florence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron Letters, 1995 , vol. 36, # 6 p. 877 - 880
反应条件
jones reagent; hydrogen; palladium on activated charcoal 1.) acetone, 0 deg C, 2 h, 2.) CH3OH, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Meffre, Patrick; Gauzy, Laurence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron, 1996 , vol. 52, # 34 p. 11215 - 11238
反应条件
1: Jones reagent 2: H2 View Scheme
参考文献
Meffre, Patrick; Gauzy, Laurence; Perdigues, Chantal; Desanges-Levecque, Florence; Branquet, Eric; Durand, Philippe; Le Goffic, Francois
Tetrahedron Letters, 1995 , vol. 36, # 6 p. 877 - 880
