乙基乙酰氧基(二乙氧基磷酰)乙酸酯合成路线 （共 7 条）
反应条件
1: glyoxylic acid ethyl ester; phosphonic acid diethyl ester With triethylamine in toluene T=0 - 20°C; Inert atmosphere; 2: acetic anhydride in toluene T=0 - 20°C;
参考文献
US2012/157383 A1, ;
Page/Page column 45 ;
US 20120157383 A1
反应条件
1: glyoxylic acid ethyl ester; phosphorous acid diethyl ester With triethylamine in toluene T=0 - 20°C; Inert atmosphere; 2: acetic anhydride in toluene T=0 - 20°C;
参考文献
HUGHES, Adam D.; FENSTER, Erik; FLEURY, Melissa; GENDRON, Roland
Patent: US2013/109639 A1, 2013 ;
Location in patent: Paragraph 0289-0290 ;
反应条件
pyridine in dichloromethane T=0°C;
参考文献
Schmidt; Langner; Kirschbaum; Braun
Synthesis, 1994 , # 11 p. 1138 - 1140
反应条件
in toluene T=20°C; 12 h;
参考文献
Helmboldt, Hannes; Koehler, Daniel; Hiersemann, Martin
Organic Letters, 2006 , vol. 8, # 8 p. 1573 - 1576
反应条件
TMG; lithium chloride
1.) THF, -78 deg C, 15 min, 2.) THF, RT, 12 h; Multistep reaction;
参考文献
Burk, Mark J.; Kalberg, Christopher S.; Pizzano, Antonio
Journal of the American Chemical Society, 1998 , vol. 120, # 18 p. 4345 - 4353
反应条件
TMG; lithium chloride in tetrahydrofuran
1.) -75 deg C, 15 min; 2.) -75 deg C --> room temp., overnight; Yield given. Yields of byproduct given;
参考文献
Schmidt; Langner; Kirschbaum; Braun
Synthesis, 1994 , # 11 p. 1138 - 1140
反应条件
TMG; lithium chloride
1.) THF, -78 deg C, 15 min, 2.) THF, RT, 12 h; Multistep reaction;
参考文献
Burk, Mark J.; Kalberg, Christopher S.; Pizzano, Antonio
Journal of the American Chemical Society, 1998 , vol. 120, # 18 p. 4345 - 4353
