4,6-二哌啶-1,3,5-三嗪-2-胺合成路线 （共 4 条）
反应条件
T=160°C; P=3000240 Torr; 20 h;
参考文献
Shibuya, Isao; Oishi, Akihiro; Yasumoto, Masahiko
Heterocycles, 1998 , vol. 48, # 8 p. 1659 - 1662
反应条件
in water T=100°C; Substitution; 4 h;
参考文献
Hajduk, Philip J.; Dinges, Juergen; Schkeryantz, Jeffrey M.; Janowick, David; Kaminski, Michele; Tufano, Michael; Augeri, David J.; Petros, Andrew; Nienaber, Vicki; Zhong, Ping; Hammond, Rachel; Coen, Michael; Beutel, Bruce; Katz, Leonard; Fesik, Stephen W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3852 - 3859
反应条件
1.1: DIPEA / tetrahydrofuran / 3 h / 0 - 20 °C 1.2: 91 percent / tetrahydrofuran / 15 h / 20 °C 2.1: 93 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Hajduk, Philip J.; Dinges, Juergen; Schkeryantz, Jeffrey M.; Janowick, David; Kaminski, Michele; Tufano, Michael; Augeri, David J.; Petros, Andrew; Nienaber, Vicki; Zhong, Ping; Hammond, Rachel; Coen, Michael; Beutel, Bruce; Katz, Leonard; Fesik, Stephen W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3852 - 3859
反应条件
1: 58 percent / DIPEA / toluene / 12 h / 90 °C 2: 93 percent / trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Hollink, Emily; Simanek, Eric E.; Bergbreiter, David E.
Tetrahedron Letters, 2005 , vol. 46, # 12 p. 2005 - 2008
