反应条件
1: 71 percent / NaOAc, Br2 / acetic acid / 1.) 80 deg C, 6 h, 2.) 25 deg C, 16 h 2: 1.) n-BuLi / 1.) ether, hexane, -70 deg C, 15 min, 2.) ether, hexane, THF, -65 deg C 3: 83.5 percent / 48percent HBr, HOAc / 0.25 h / 100 °C 4: 59 percent / H2 / W-2 Raney Ni / tetrahydrofuran; ethanol / 6 h 5: 1.) t-BuLi, 2.) CH3OH / 1.) toluene, ether, pentane, -100 deg C, 20 min, 2.) toluene, ether, pentane, - 85 deg C View Scheme
参考文献
Bargar, T. M.; Wilson, T.; Daniel, J. K.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 1583 - 1592
