6-甲基-4-苯基香豆素合成路线 （共 47 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C; Kostanecki acylation; 10 h;
参考文献
Hwang, In-Taek; Lee, Sun-Ah; Hwang, Jin-Soo; Lee, Kee-In
Molecules, 2011 , vol. 16, # 8 p. 6313 - 6321
反应条件
1: 6-methylcoumarin With 1,10-phenanthroline; oxygen; palladium diacetate in N,N-dimethyl-formamide Heck type reaction; 0.0833333 h; 2: 3,4,5-trimethoxyphenylboronic acid in N,N-dimethyl-formamide T=100°C; Heck type reaction; 24 h; regioselective reaction;
参考文献
Khoobi, Mehdi; Alipour, Masoumeh; Zarei, Samaneh; Jafarpour, Farnaz; Shafiee, Abbas
Chemical Communications, 2012 , vol. 48, # 24 p. 2985 - 2987
反应条件
palladium diacetate; calcium carbonate in methanol T=60°C; Heck Reaction;
参考文献
Barancelli, Daniela A.; Salles, Airton G.; Taylor, Jason G.; Correia, Carlos Roque D.
Organic Letters, 2012 , vol. 14, # 23 p. 6036 - 6039
反应条件
4-(N,N-dimethlyamino)pyridine in toluene Wittig reaction; 72 h; Inert atmosphereReflux;
参考文献
Gallagher, Brian D.; Taft, Benjamin R.; Lipshutz, Bruce H.
Organic Letters, 2009 , vol. 11, # 23 p. 5374 - 5377
反应条件
N,N-dicyclohexylmethylamine; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in 1,4-dioxane T=80°C; 18 h; Product distribution / selectivity;
参考文献
WO2012/98044 A1, ;
Page/Page column 16-17 ;
反应条件
tetrakis(triphenylphosphine) palladium(0); caesium carbonate in water; toluene T=80°C; Suzuki-Miyaura cross-coupling; 12 h;
参考文献
Wu, Jie; Zhang, Liang; Xia, Hong-Guang
Tetrahedron Letters, 2006 , vol. 47, # 10 p. 1525 - 1528
反应条件
potassium phosphate; CM-phos; palladium diacetate; triethylamine in tert-butyl alcohol T=50°C; Suzuki coupling; 4 h; Inert atmosphere;
参考文献
Wong, Pui Yu; Chow, Wing Kin; Chung, Kin Ho; So, Chau Ming; Lau, Chak Po; Kwong, Fuk Yee
Chemical Communications, 2011 , vol. 47, # 29 p. 8328 - 8330
反应条件
sulfuric acid in ethyl acetate T=20°C; 12 h;
参考文献
Chemical Communications, , # 31 p. 3296 - 3298
反应条件
1: 84 percent / DCC; 4-dimethylaminopyridine / 20 °C 2: 50 percent / TFA / Pd(OAc)2 / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 22 p. 7516 - 7522
反应条件
1: 84 percent / DCC; 4-dimethylaminopyridine / 20 °C 2: 50 percent / TFA / Pd(OAc)2 / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 22 p. 7516 - 7522
