1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: bromobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: iodobenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

1: 1-(methanesulfonyl)piperidine With zinc(II) chloride; lithium hexamethyldisilazane in tetrahydrofuran T=-20 - 20°C; 1 h; Inert atmosphere; 2: trifluoromethanesulfonyloxybenzene With palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran T=20 - 65°C; Negishi coupling reaction; Inert atmosphere;

triethylamine in pyridine Ambient temperature;

benzene

piperidine in acetonitrile HeatingSoxhlet apparatus with MgSO4;

1: 21 percent / m-chloroperoxybenzoic acid (50percent) / CHCl3 / 168 h / Ambient temperature 2: piperidine / acetonitrile / Heating; Soxhlet apparatus with MgSO4 View Scheme

1: 80 percent / NaOMe / methanol / Heating 2: 21 percent / m-chloroperoxybenzoic acid (50percent) / CHCl3 / 168 h / Ambient temperature 3: piperidine / acetonitrile / Heating; Soxhlet apparatus with MgSO4 View Scheme

formaldehyd in acetonitrile HeatingSoxhlet apparatus with MgSO4;

1: 65 percent / piperidine / acetonitrile / Heating; Soxhlet apparatus with MgSO4 2: 15 percent / formaline (37percent) / acetonitrile / Heating; Soxhlet apparatus with MgSO4 View Scheme