hydrogen; palladium on activated charcoal in tetrahydrofuran 14 h;

hydrogenchloride 4 h; Heating;

1: With chloro-trimethyl-silane; triethylamine 2: With 1,1-dimethylethylmagnesium chloride 3: With palladium on activated charcoal; hydrogen

oxygen; sodium acetate; acetaldehyde; ruthenium trichloride in ethyl acetate T=40°C;

1: (S)-4-carboxy-2-azetidinone With 2,3,4,5,6-pentafluorophenol; dicyclohexyl-carbodiimide in 1,4-dioxane; N,N-dimethyl-formamide T=0°C; 3.5 h; 2: L-histidinyl-L-prolinamide in 1,4-dioxane; N,N-dimethyl-formamide T=0°C; 2 h;