3-溴-N,N-二甲基苯胺合成路线 （共 26 条）
反应条件
1.1: Mg / tetrahydrofuran / 2 h / Heating
1.2: sulfur / tetrahydrofuran / 2 h / Heating
2.1: 0.79 g / dihexyl telluride; H2O2 / 1 h
3.1: sec-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 1 h / -78 °C
3.2: 51 percent / tetrahydrofuran; cyclohexane / -78 - 20 °C
4.1: 13 percent / lithium diisopropylamide / tetrahydrofuran; hexane / 15 h / 25 °C
View Scheme
参考文献
Detty, Michael R.; Prasad, Paras N.; Donnelly, David J.; Ohulchanskyy, Tymish; Gibson, Scott L.; Hilf, Russell
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 10 p. 2537 - 2544
反应条件
1: 3 -bromo -N,N-dimethylaniline With n-butyllithium in tetrahydrofuran; cyclohexane
T=-78°C; 0.25 h; Schlenk techniqueInert atmosphere;
2: acetone in tetrahydrofuran; cyclohexane
T=-78°C; 0.25 h; Schlenk techniqueInert atmosphere;
参考文献
Pastierik, Tomas; Sebej, Peter; Medalova, Jirina; Stacko, Peter; Klan, Petr
Journal of Organic Chemistry, 2014 , vol. 79, # 8 p. 3374 - 3382
反应条件
bromine; acetic acid
参考文献
Vorlaender; Siebert
Chemische Berichte, 1919 , vol. 52, p. 285
参考文献
Vorlaender; Siebert
Chemische Berichte, 1919 , vol. 52, p. 285
反应条件
trichlorophosphate in N-methyl-acetamide
参考文献
Astra Lakemedel Aktiebolag
Patent: US3996381 A1, 1976 ;
反应条件
water; trichlorophosphate
Yield given. Multistep reaction;
参考文献
Meyer, Walter E.; Tomcufcik, Andrew S.; Chan, Peter S.; Emma, John E.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1705 - 1710
