1-甲氧基-4-苯氧基苯合成路线 （共 73 条）
反应条件
in N,N-dimethyl-formamide
T=100°C; 24 h;
参考文献
Huang; Zhu; Xu
Synthetic Communications, 2001 , vol. 31, # 18 p. 2823 - 2828
反应条件
in acetonitrile-D3
T=80°C; 1 h; Inert atmosphereDarkness; regioselective reaction;
参考文献
Wang, Bijia; Graskemper, Joseph W.; Qin, Linlin; DiMagno, Stephen G.
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4079 - 4083
反应条件
potassium carbonate in dimethyl sulfoxide
0.166667 h; RefluxMicrowave irradiation;
参考文献
Sarkate, Aniket P.; Bahekar, Sushilkumar S.; Wadhai, Vijay M.; Ghandge, Ganesh N.; Wakte, Pravin S.; Shinde, Devanand B.
Synlett, 2013 , vol. 24, # 12 art. no. ST-2013-B0227-L, p. 1513 - 1516
反应条件
potassium carbonate in acetonitrile
T=50°C; 6 h; Overall yield = 93 percent; regioselective reaction;
参考文献
Kakinuma, Yohji; Moriyama, Katsuhiko; Togo, Hideo
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-F0786-OP, p. 183 - 188
反应条件
potassium carbonate in acetonitrile
T=50°C; 6 h; Overall yield = 90 percent; regioselective reaction;
参考文献
Kakinuma, Yohji; Moriyama, Katsuhiko; Togo, Hideo
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-F0786-OP, p. 183 - 188
反应条件
1: iodine; dipotassium peroxodisulfate
2: potassium carbonate / acetonitrile / 30 h / 50 °C
View Scheme
参考文献
Kakinuma, Yohji; Moriyama, Katsuhiko; Togo, Hideo
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-F0786-OP, p. 183 - 188
反应条件
potassium hydroxide in N,N-dimethyl-formamide
参考文献
Jiang, Xiaolu; Zhou, Lu; Wei, Dengguo; Meng, Hu; Liu, Ying; Lai, Luhua
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 24 p. 6549 - 6552
反应条件
1.2.3.4-tetrahydro-8-hydroxy-quinoline; caesium carbonate; copper(I) bromide in N,N-dimethyl-formamide
T=130°C; 48 h; Inert atmosphere;
参考文献
Li, Yaming; Li, Xiaoying; Wang, Huifeng; Chen, Tao; Xie, Yusheng
Synthesis, 2010 , # 21 art. no. F10410SS, p. 3602 - 3608
反应条件
1: Cu / 195 °C
2: Fe, AcOH / H2O; methanol
3: (i) aq. HBr, NaNO2, (ii) CuBr, aq. HBr
4: Cu, 4-methoxy-phenol <K salt> / 220 - 230 °C
View Scheme
参考文献
Forrest,J.
Journal of the Chemical Society, 1960 , p. 581 - 588
反应条件
1: Fe, AcOH / H2O; methanol
2: (i) aq. HBr, NaNO2, (ii) CuBr, aq. HBr
3: Cu, 4-methoxy-phenol <K salt> / 220 - 230 °C
View Scheme
参考文献
Forrest,J.
Journal of the Chemical Society, 1960 , p. 581 - 588
