4-孕烷-17α,20β-二醇-3-酮合成路线 （共 9 条）
反应条件
sodium tetrahydroborate in methanol T=0 - 5°C; 1.5 h;
参考文献
Kovganko; Kashkan; Shkumatov
Chemistry of Natural Compounds, 2001 , vol. 37, # 1 p. 55 - 56
反应条件
reduced form (20β-NADH); NADP; 20β-hydroxysteroid dehydrogenase in dichloromethane; water T=37°C; 20β-hydroxysteroid dehydrogenase activity with various cofactors and pH-s;
参考文献
Ouedraogo, Yannick P.; Huang, Longchuan; Torrente, Mariana P.; Proni, Gloria; Chadwick, Ekaterina; Wehmschulte, Rudolf J.; Nesnas, Nasri
Chirality, 2013 , vol. 25, # 9 p. 575 - 581
反应条件
1: With ethanol; S. cerevisiae GRF18; YEp5117α 30 h; 2: With chromic acid in isopropyl alcohol; acetone T=20°C; 0.333333 h;
参考文献
Shkumatov; Usova; Radyuk; Kashkan; Kovganko; Juretzek; Mauersberger
Russian Journal of Bioorganic Chemistry, 2003 , vol. 29, # 6 p. 581 - 587
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 4 h / |Reflux 2: ammonia; sulfuric acid; titanium (III) sulphate / methanol / 10 h 3: sodium tetrahydroborate / methanol / 0.5 h View Scheme
参考文献
Ouedraogo, Yannick P.; Huang, Longchuan; Torrente, Mariana P.; Proni, Gloria; Chadwick, Ekaterina; Wehmschulte, Rudolf J.; Nesnas, Nasri
Chirality, 2013 , vol. 25, # 9 p. 575 - 581
反应条件
1: ammonia; sulfuric acid; titanium (III) sulphate / methanol / 10 h 2: sodium tetrahydroborate / methanol / 0.5 h View Scheme
参考文献
Ouedraogo, Yannick P.; Huang, Longchuan; Torrente, Mariana P.; Proni, Gloria; Chadwick, Ekaterina; Wehmschulte, Rudolf J.; Nesnas, Nasri
Chirality, 2013 , vol. 25, # 9 p. 575 - 581
反应条件
ethanol; Saccharomyces cerevisiae GRF18; YEp5117α 30 h;
参考文献
Shkumatov; Usova; Radyuk; Kashkan; Kovganko; Juretzek; Mauersberger
Russian Journal of Bioorganic Chemistry, 2003 , vol. 29, # 6 p. 581 - 587
参考文献
Schering A.G.
Patent: DE765448 , 1938 ;
DRP/DRBP Org.Chem.
参考文献
Schering Corp.
Patent: US2265143 , 1939 ;
参考文献
Butenandt; Schmidt-Thome; Paul
Chemische Berichte, 1938 , vol. 71, p. 1313,1315
Full Text Show Details
Ruzicka; Goldberg; Hardegger
Helvetica Chimica Acta, 1942 , vol. 25, p. 1297,1302-1305
