二乙氧基磷酰-苯基-甲醇合成路线 （共 37 条）
反应条件
in toluene
2 h; Reflux;
参考文献
Kaboudin, Babak; Karami, Leila; Kato, Jun-Ya; Aoyama, Hiroshi; Yokomatsu, Tsutomu
Tetrahedron Letters, 2013 , vol. 54, # 36 p. 4872 - 4875
反应条件
1: glycylleucine methyl ester; benzaldehyde With Pc-t-AlCl in methanol
T=20°C; Kabachnik-Fields reaction; 6 h; Molecular sieve;
2: phosphorous acid diethyl ester in methanol
T=20°C; Kabachnik-Fields reaction; 72 h;
参考文献
Matveeva; Podrugina; Prisyazhnoi; Bachurin; Zefirov
Russian Chemical Bulletin, 2010 , vol. 59, # 1 p. 200 - 208
反应条件
in acetonitrile
T=0°C;
参考文献
Ofitserov, E. N.; Mironov, V. F.; Ofitserova, E. Kh.; Konovalova, I. V.; Pudovik, A. N.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 12 p. 2704 - 2715,2385 - 2394
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane
5 h; Ambient temperature;
参考文献
Costisella, Burkhard; Keitel, Iris
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 40, p. 161 - 166
反应条件
1: 2-aminopyridine; benzaldehyde With tetra-tert-butyl-phthalocyanine aluminum chloride in dichloromethane
T=20°C; Kabachnik-Fields reaction; 3 h; Molecular sieve;
2: phosphorous acid diethyl ester in dichloromethane
T=20°C; Kabachnik-Fields reaction; 21 h; Molecular sieve;
参考文献
Matveeva; Podrugina; Kolesnikova; Borisenko; Zefirov
Russian Chemical Bulletin, 2009 , vol. 58, # 1 p. 119 - 125
反应条件
1: 100 °C / Heating
2: CF3CO2H / methanol / Ambient temperature
View Scheme
参考文献
Creary, Xavier; Underiner, Ted L.
Journal of Organic Chemistry, 1985 , vol. 50, # 12 p. 2165 - 2170
参考文献
Nuretdinov, I. A.; Grishina, L. N.
Russian Journal of General Chemistry, 1998 , vol. 68, # 12 p. 1963 - 1964
Zhurnal Obshchei Khimii, 1998 , vol. 68, # 12 p. 2051 - 2052
反应条件
1: lithium bis(trimethylsilylamide) (LHMS) / tetrahydrofuran / -78 °C
2: 95 percent Spectr. / NaOH / var. reaction temperatures and quant. of benzaldehyde; syn/anti ratio of the diastereoisomeric hydroxy acids (3)
View Scheme
参考文献
Longmire, Cynthia F.; Evans, Slayton A.
Journal of the Chemical Society, Chemical Communications, 1990 , # 13 p. 922 - 923
反应条件
2: methanol / Heating
View Scheme
参考文献
Sekiguchi,A. et al.
Bulletin of the Chemical Society of Japan, 1978 , vol. 51, p. 337 - 338
反应条件
chloro-trimethyl-silane; zinc
1) ether, r.t., 2.5 h, 2) ether, r.t., 30 min; Yield given. Multistep reaction;
参考文献
Sekine, Mitsuo; Yamagata, Hiraku; Hata, Tsujiaki
Journal of the Chemical Society, Chemical Communications, 1981 , # 18 p. 970 - 971
