(±)-2-氯-1-苯基乙醇合成路线 （共 94 条）
反应条件
[Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate; bovine serum albumin in dimethyl sulfoxide; toluene T=20°C; pH=8.0; 6 h; aq. bufferInert atmosphereResolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Jerphagnon, Thomas; Gayet, Arnaud J.A.; Berthiol, Florian; Ritleng, Vincent; Mrsic, Natasa; Meetsma, Auke; Pfeffer, Michel; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12780 - 12790
反应条件
sodium hydroxide in tetrahydrofuran T=25°C; Title compound not separated from byproducts;
参考文献
Huang, Kun; Wang, Haiyang; Stepanenko, Viatcheslav; De Jesus, Melvin; Torruellas, Carilyn; Correa, Wildeliz; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2011 , vol. 76, # 6 p. 1883 - 1886
反应条件
halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; Dehydrochlorination; pH=7.5; Title compound not separated from byproducts;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; kinetic resolution; pH=7.5;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
epoxide hydrolase from Agrobacterium radiobacter AD1; halohydrin dehalogenase from Agrobacterium radiobacter AD1; Tris-SO4 buffer in water T=30°C; kinetic resolution; pH=7.5;
参考文献
Lutje Spelberg, Jeffrey H.; Van Hylckama Vlieg, Johan E. T.; Bosma, Tjibbe; Kellogg, Richard M.; Janssen, Dick B.
Tetrahedron Asymmetry, 1999 , vol. 10, # 15 p. 2863 - 2870
反应条件
sodium dichromate; sulfuric acid T=60°C;
参考文献
Journal of the Chemical Society, , p. 114
参考文献
Bulletin de la Societe Chimique de France, , vol. <4> 31, p. 178
反应条件
(η5-C5Ph5)Ru(CO)2Cl; PS-C "Amano II"; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 13 h;
参考文献
Martin-Matute, Belen; Edin, Michaela; Bogar, Krisztian; Kaynak, F. Betuel; Baeckvall, Jan-E.
Journal of the American Chemical Society, 2005 , vol. 127, # 24 p. 8817 - 8825
反应条件
triethylamine; planar-chiral DMAP derivative in 1,1-dimethylpropan-1-ol T=0°C; Acetylation;
参考文献
Ruble, J. Craig; Tweddell, Jennifer; Fu, Gregory C.
Journal of Organic Chemistry, 1998 , vol. 63, # 9 p. 2794 - 2795
反应条件
1: 1-hydroxy-2-chloroethylbenzene With Burkholderia cepacia lipase in diethyl ether T=30°C; 0.5 h; Enzymatic reaction; 2: vinyl acetate in diethyl ether T=30°C; 2.5 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Ema, Tadashi; Ura, Norichika; Yoshii, Masataka; Korenaga, Toshinobu; Sakai, Takashi
Tetrahedron, 2009 , vol. 65, # 46 p. 9583 - 9591
