3-(叔丁氧基羰基)苯甲酸合成路线 （共 7 条）
反应条件
LiOH; methyl iodide in methanol; N,N-dimethyl-formamide
参考文献
Ferring-Research Limited; Yamanouchi Pharmaceutical Co. Ltd.
Patent: US5728829 A1, 1998 ;
反应条件
1: With sodium hydroxide; water in methanol T=70°C; 0.5 h; 2: With hydrogenchloride in water
参考文献
Japan Tobacco Inc.
Patent: US2006/35939 A1, 2006 ;
Location in patent: Page/Page column 19 ;
反应条件
1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature 2: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature 2: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
sodium hydrogencarbonate in 1,4-dioxane; water
参考文献
Deberardinis, Albert M.; Banerjee, Upasana; Hadden, M. Kyle
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 7 p. 590 - 595
反应条件
sodium hydride 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h; Yield given. Multistep reaction;
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
反应条件
1: acetone / 0.5 h 2: aq. NaN3 / acetone / 1 h 3: toluene / 2 h / Heating 4: CH2Cl2 / 0.5 h / Ambient temperature 5: aq. HCl / ethyl acetate / 3 h View Scheme
参考文献
Semple, Graeme; Ryder, Hamish; Rooker, David P.; Batt, Andrzej R.; Kendrick, David A.; Szelke, Michael; Ohta, Mitsuaki; Satoh, Masato; Nishida, Akito; Akuzawa, Shinobu; Miyata, Keiji
Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 331 - 341
