1: CH2Cl2 / 0.5 h / Ambient temperature 2: aq. HCl / ethyl acetate / 3 h View Scheme

<b>Multi-step reaction with 5 steps<br /> </b>1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature<br />2: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h<br />3: acetone / 0.5 h<br />4: aq. NaN₃ / acetone / 1 h<br />5: toluene / 2 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: 91 percent / 2M aq. KOH / dioxane / Ambient temperature<br />2: 1.) NaH / 1.) DMF, from 10 deg C to RT, 1 h, 2.) DMF, RT, 2 h<br />3: acetone / 0.5 h<br />4: aq. NaN₃ / acetone / 1 h<br />5: toluene / 2 h / Heating<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 65 h / 70 &deg;C / |Inert atmosphere<br />2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 10 - 20 &deg;C<br />2.2: 0.5 h / 5 &deg;C<br />3.1: lithium hydroxide / methanol; water / 20 &deg;C<br />4.1: triethylamine / acetone / 0.5 h / 0 - 5 &deg;C / |Inert atmosphere<br />4.2: 1 h / 0 - 5 &deg;C<br />4.3: 2 h / |Reflux; |Inert atmosphere<br /> <br /> &nbsp;