2-氨基-3-羟基吡啶合成路线 （共 143 条）
反应条件
1: With sodium cyanoborohydride in water; acetonitrile 4 h; 2: With acetic acid in acetonitrile
参考文献
Inkster, James A. H.; Guerin, Brigitte; Ruth, Thomas J.; Adam, Michael J.
Journal of Labelled Compounds and Radiopharmaceuticals, 2008 , vol. 51, # 14 p. 444 - 452
参考文献
Rydzkowski, R.; Blondeau, D.; Sliwa, H.
Tetrahedron Letters, 1985 , vol. 26, # 21 p. 2571 - 2574
反应条件
trichlorophosphate in water; toluene
参考文献
ACTAVIS GROUP PTC EHF
Patent: US2010/4447 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
1: toluene-4-sulfonic acid / xylene / 20.5 h / 25 - 142 °C 2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 21 h / 38 - 43 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash, Dhar; PATEL, Dhimant, Jasubhai; ROY, Rushikesh, Udaykumar; PATEL, Mayur, Ramnikbhai
Patent: WO2011/73997 A2, 2011 ;
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin T=85°C; 0.333333 h;
参考文献
Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra
Monatshefte fur Chemie, 2011 , vol. 142, # 1 p. 87 - 91
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin T=85°C; 0.333333 h;
参考文献
Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra
Monatshefte fur Chemie, 2011 , vol. 142, # 1 p. 87 - 91
反应条件
sodium hydrogencarbonate in water; butanone 1.) room temperature, 30 min, 2.) 75 deg C, 30 min;
参考文献
Savelon; Bizot-Espiard; Caignard; Pfeiffer; Renard; Viaud; Guillaumet
Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 2 p. 133 - 142
反应条件
(i) NaOMe, DMSO, (ii) /BRN= 1102743/; Multistep reaction;
参考文献
Clauson-Kaas,N. et al.
Acta Chemica Scandinavica (1947-1973), 1969 , vol. 23, p. 2322 - 2324
反应条件
1,3-dibromo-5,5-dimethyl-hydantoin T=85°C; 0.116667 h;
参考文献
Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra
Monatshefte fur Chemie, 2011 , vol. 142, # 1 p. 87 - 91
反应条件
T=250°C; 0.0333333 h; microwave irradiation;
参考文献
Myllymaeki, Mikko J.; Koskinen, Ari M.P.
Tetrahedron Letters, 2007 , vol. 48, # 13 p. 2295 - 2298
