2-氨基-3-羟基吡啶合成路线 （共 143 条）
反应条件
1: Py / 1 h / Ambient temperature 2: H2O / 1 h 3: SOCl2 / CHCl3 4: acetone / 4 h / 35 °C View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
sodium acetate in ethanol
参考文献
Mital,R.L.; Jain,S.K.
Journal of the Chemical Society [Section] C: Organic, 1971 , p. 1875 - 1878
反应条件
1: in diethylene glycol dimethyl ether T=80°C; 6 h; 2: With toluene-4-sulfonic acid in diethylene glycol dimethyl ether T=80°C; 48 h;
参考文献
ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan
Patent: WO2009/139709 A1, 2009 ;
Location in patent: Page/Page column 54-55 ;
WO 2009/139709 A1
反应条件
p-toluenesulfonic acid monohydrate in methanol; diethylene glycol dimethyl ether
参考文献
Cowart, Marlon D.
Patent: US2004/2488 A1, 2004 ;
反应条件
in diethylene glycol dimethyl ether T=60°C; 4 h;
参考文献
Mylari, Banavara L.; Scott, Pamela J.; Zembrowski, William J.
Synthetic Communications, 1989 , vol. 19, # 16 p. 2921 - 2924
反应条件
methanol in diethyl ether T=20°C; Methylation;
参考文献
Trapani, Giuseppe; Franco, Massimo; Latrofa, Andrea; Ricciardi, Laura; Carotti, Angelo; Serra, Mariangela; Sanna, Enrico; Biggio, Giovanni; Liso, Gaetano
Journal of Medicinal Chemistry, 1999 , vol. 42, # 19 p. 3934 - 3941
反应条件
in methanol; benzene
参考文献
Merck and Co., Inc.
Patent: US5972975 A1, 1999 ;
参考文献
Rydzkowski, R.; Blondeau, D.; Sliwa, H.
Tetrahedron Letters, 1985 , vol. 26, # 21 p. 2571 - 2574
反应条件
1: 77 percent / tetrahydrofuran / 6 h / Heating 2: 1.) EtONa / 1.) EtOH, RT, 1 h, 2.) DMF, 110 deg C, 1 h View Scheme
参考文献
Flouzat, Christine; Bresson, Yvette; Mattio, Anny; Bonnet, Jacqueline; Guillaumet, Gerald
Journal of Medicinal Chemistry, 1993 , vol. 36, # 4 p. 497 - 503
反应条件
1.1: trichlorophosphate / 1 h / 30 - 35 °C 1.2: 24 h / 35 - 40 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2 h / 50 - 55 °C / Inert atmosphere 2.2: Inert atmosphere 2.3: 2 h / 5 - 85 °C 3.1: sodium carbonate / methanol / 70 - 75 °C / Inert atmosphere; Pressure vessel View Scheme
参考文献
AUROBINDO PHARMA LIMITED; VUNDELA, Sailaja; PARVEZ, Sayyed, Asif; VEKARIYA, Nagaji, Ambabhai; ISLAM, Aminul; SIVAKUMARAN, Meenakshisunderam
Patent: WO2012/42368 A1, 2012 ;
