1: trisodium 1,3,5-naphthalenetrisulfonate With calcium hydroxide powder; sodium hydroxide in water T=310°C; P=37503.8 Torr; 5 h; 2: With hydrogenchloride in H20 pH=7.0; Heating / reflux; 3: acetic anhydride With hydrogenchloride; sodium hydroxide more than 3 stages;

1: 3-hydroxy-2-methyl-benzoic acid With sodium hydroxide in water pH=6.9; 2: acetic anhydride With sodium hydroxide T=0 - 5°C; pH=8.8 - 9.2; 4 h; 3: With hydrogenchloride T=5°C; pH=3.8 - 4.2;

hydrogenchloride; sodium hydroxide in water; acetic anhydride

sodium hydroxide; sulfuric acid; acetic anhydride; magnesium sulfate; sodium nitrite; palladium monocarbide in pyridine; ethanol; ethyl acetate; toluene

sulfuric acid T=20 - 44°C; 2 h;

1: 72 percent / EDCI; HOBt 2: 100 percent / HCl / methanol / 3 h / 40 °C 3: 59 percent / TsCl; Et3N View Scheme

thionyl chloride T=80 - 170°C; 2 h;