(S)-3-异丙基-2,5-哌嗪二酮合成路线 （共 29 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=60 - 65°C; 72 h;
参考文献
Schering Corporation
Patent: WO2004/46111 A1, 2004 ;
Location in patent: Page 26-27 ;
反应条件
in dichloromethane 72 h; Ambient temperature;
参考文献
Schoellkopf, Ulrich; Groth, Ulrich; Deng, Chuanzheng
Angewandte Chemie, 1981 , vol. 93, # 9 p. 793 - 795
反应条件
1: 86 percent / LAH / tetrahydrofuran / 72 h / 60 - 65 °C 2: 74 percent / Na2CO3 / diethyl ether; H2O; toluene / 1 h / 0 °C 3: 79 percent / LAH / tetrahydrofuran / 72 h / 60 - 65 °C View Scheme
参考文献
Falorni, Massimo; Giacomelli, Giampaolo; Lardicci, Luciano
Gazzetta Chimica Italiana, 1990 , vol. 120, p. 765 - 769
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=60 - 65°C; 72 h;
参考文献
Gazzetta Chimica Italiana, , vol. 120, p. 765 - 769
反应条件
in dichloromethane T=20°C; 48 h;
参考文献
PFIZER LIMITED; PFIZER INC.
Patent: WO2004/56787 A1, 2004 ;
Location in patent: Page 50 ;
WO 2004/056787 A1
反应条件
in dichloromethane T=20°C; 72 h;
参考文献
Ma; Liu; Li; Flippen-Anderson; Yu; Cook
Journal of Organic Chemistry, 2001 , vol. 66, # 13 p. 4525 - 4542
反应条件
tetrafluoroboric acid diethyl ether complex in diethyl ether; dichloromethane 168 h; Ambient temperature;
参考文献
Groth, Ulrich; Schmeck, Carsten; Schoellkopf, Ulrich
Liebigs Annalen der Chemie, 1993 , # 3 p. 321 - 324
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Chemical Communications, , # 6 p. 659 - 660
反应条件
1: CH2Cl2 / 6 h
2: 2M aq. HCl / 12 h
View Scheme
参考文献
Bull, Steven D.; Davies, Stephen G.; Moss, William O.
Tetrahedron Asymmetry, 1998 , vol. 9, # 2 p. 321 - 327
