N,N-二乙基苯甲酰胺合成路线 （共 244 条）
反应条件
1.1: s-BuLi; TMEDA / tetrahydrofuran; cyclohexane / 1 h / -78 °C 1.2: tetrahydrofuran; cyclohexane / -78 - 20 °C 1.3: 94 percent / aq. HCl; NH4Cl / tetrahydrofuran; cyclohexane / pH 5 - 6 2.1: 79 percent / Pd(PPh3)4; aq. Na2CO3 / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Fu, Jian-Min; Snieckus, Victor
Canadian Journal of Chemistry, 2000 , vol. 78, # 6 p. 905 - 919
反应条件
Destillieren des Reaktionsprodukts unter vermindertem Druck;
参考文献
v. Braun; Pinkernelle
Chemische Berichte, 1934 , vol. 67, p. 1218
反应条件
1.1: sec-BuLi; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; cyclohexane / 0.67 h / -78 °C
1.2: 2.58 g / tetrahydrofuran; cyclohexane / 1 h / -78 - 20 °C
2.1: 1.6 g / NaBH4 / methanol / 0.5 h / 0 - 20 °C
View Scheme
参考文献
Chen, Chin-Wen; Beak, Peter
Journal of Organic Chemistry, 1986 , vol. 51, # 17 p. 3325 - 3334
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in diethyl ether
1.) -78 deg C, 1 h, 2.) -78 deg C -> RT, 12 h;
参考文献
Watanabe; Snieckus
Journal of the American Chemical Society, 1980 , vol. 102, # 4 p. 1457 - 1460
反应条件
1: sec-BuLi, TMEDA / tetrahydrofuran / -78 °C
2: NaBH4 / methanol
3: 94 percent / NaH / tetrahydrofuran
4: 8 percent / pentane / 3 h / -78 °C
5: TsOH / toluene / Heating
6: O3 / methanol
7: NaBH4 / methanol
8: pyridine
9: NaBH4 / dimethylsulfoxide
View Scheme
参考文献
Kawasaki, Takeshi; Kimachi, Tetsutaro
Synlett, 1998 , # 12 p. 1429 - 1431
反应条件
silver hexafluoroantimonate; [{RuCl2(cymene)}2]; sodium acetate in 1,2-dichloro-ethane
T=120°C; 24 h; Sealed tubeInert atmosphere; chemoselective reaction;
参考文献
Liu, Weiping; Ackermann, Lutz
Chemical Communications, 2014 , vol. 50, # 15 p. 1878 - 1881
反应条件
1: tert-BuLi / tetrahydrofuran / -78 °C
2: KCN, 18-crown-6 / CH2Cl2 / 0.17 h
3: acetic acid / 5 h / 23 °C
View Scheme
参考文献
Okazaki, Kousuke; Nomura, Keiichi; Yoshii, Eiichi
Synthetic Communications, 1987 , vol. 17, # 9 p. 1021 - 1028
反应条件
1: s-BuLi; TMEDA / tetrahydrofuran
2: LDA / tetrahydrofuran / -78 - 20 °C
3: 89 percent / NaH / tetrahydrofuran / 10 h / 20 °C
View Scheme
参考文献
Pradhan, Tarun Kanti; De, Asish; Mortier, Jacques
Tetrahedron, 2005 , vol. 61, # 38 p. 9007 - 9017
反应条件
water; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate); copper(I) bromide in acetonitrile
参考文献
Jin, Zhuang; Xu, Bo; Hammond, Gerald B.
Tetrahedron Letters, 2011 , vol. 52, # 16 p. 1956 - 1959
反应条件
1: sec-BuLi, TMEDA / tetrahydrofuran / -78 °C
2: NaBH4 / methanol
3: 94 percent / NaH / tetrahydrofuran
4: 8 percent / pentane / 3 h / -78 °C
5: TsOH / toluene / Heating
View Scheme
参考文献
Kawasaki, Takeshi; Kimachi, Tetsutaro
Synlett, 1998 , # 12 p. 1429 - 1431
