N,N-二乙基苯甲酰胺合成路线 （共 244 条）
反应条件
1: CH2Cl2 / 1 h / 50 °C
2: Et3N-3HF / CH2Cl2 / 0.5 h / 140 °C
View Scheme
参考文献
Suwada, Mitsuhiro; Fukuhara, Tsuyoshi; Hara, Shoji
Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1121 - 1125
反应条件
in tetrahydrofuran; dichloromethane; cyclohexane; water
参考文献
Kyowa Hakko Kogyo Co., Ltd.
Patent: US4849441 A1, 1989 ;
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1.) THF, -78 deg C; Multistep reaction;
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
2: 86 percent / Zn, 10percent KOH / pyridine / 21 h / Heating
View Scheme
参考文献
Ray, Jayanta K.; Harvey, Ronald G.
Journal of Organic Chemistry, 1982 , vol. 47, # 17 p. 3335 - 3336
反应条件
1: N,N-diethyl benzamide With sec.-butyllithium
2: ethyl iodide
参考文献
Clayden, Jonathan; Lai, Lai Wah
Tetrahedron Letters, 2001 , vol. 42, # 18 p. 3163 - 3166
反应条件
1: s-BuLi, TMEDA / tetrahydrofuran
2: 81 percent / LDA / tetrahydrofuran; hexane / 0.5 h / 0 °C
View Scheme
参考文献
Gray, Matthew; Chapell, Brian J.; Taylor, Nicholas J.; Snieckus, Victor
Angewandte Chemie, 1996 , vol. 108, # 13/14 p. 1609 - 1611
反应条件
N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium
1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h; Yield given. Multistep reaction;
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
oxygen; nitrogen(IV) oxide; ozone in 1,2-dichloro-ethane
T=0°C; 7 h; Product distribution;
参考文献
Suzuki, Hitomi; Tomaru, Jun-ichiro; Murashima, Takashi
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2413 - 2416
反应条件
sec.-butyllithium
1) cyclohexane, THF, -105 deg C, 1 h, 2) THF, -105 deg C, 1 h; Product distribution;
参考文献
Watanabe; Date; Kawanishi; Hori; Furukawa
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 10 p. 2637 - 2643
反应条件
Li(1+)*C12H28AlO3(1-) in tetrahydrofuran; hexane
T=0°C; 2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Kim, Sunggak; Ahn, Kyo Han
Journal of Organic Chemistry, 1984 , vol. 49, # 10 p. 1717 - 1724
